First Appearance: Spider-Man 2099 #1
While working at a company called Alchemax, Miguel O'Hara created a program that tried to create a breed of corporate-controlled super heroes. Later tricked into taking a highly addictive drug by his boss in an attempt to control him, O'Hara tried to cure himself by enhancing his DNA with his own work. The process was sabotaged by a jealous subordinate, which led to Miguel's DNA being replaced with 50% spider DNA, giving Miguel the powers of Spider-Man! Now, as Spider-Man 2099, he fights crime around the New York City of the future.
See also: All-New Spider-Man 2099